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Online glucose control to Improve Production of Antibodies
Patrick Priem, Senior Research Associate, Genmab B.V.
The Biosenz instrument has simplified integration of glucose measurement and control with a bioreactor process. The highly accurate measurement obtained from automated samples presents unique opportunities for process improvement. CHO cells were cultivated under varying glucose concentrations and feeding schemes, comparing the amount of glycated antibody produced. Undesirable glycation of protein product was eliminated by switching from manual measurement and feeding of glucose to automated measurement of glucose and feed-forward control of glucose by on-line measurements with the BioSenz.
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