| |
The stirred tank reactor (STR) is the most widely
used bioreactor type. Applikon offers a unique product, the Bio Clave,
as an autoclavable stainless steel bioreactor for cell culture and microbial
culture applications.
The Bio Clave bioreactors are versatile, easy to use systems that offer
economical alternatives to steam-in-place bioreactors and fermentors The
Bio Clave range combines the advantages of both the steam-in place bioreactor
(robust design and pressurizable) and the glass autoclavable bioreactors
(flexibility and modularity). The 316L stainless steel vessels are constructed
according to the latest standard on hygienic processing and cGMP. The
interior finish of the vessel is electropolished to Ra=0.4µm, while the
exterior is mirror polished. The high-grade surface finish secures a better
cleanability. The systems are built according to the specific demands
of a process using an extensive array of standard components. Because
of the modularity and flexibility, the user can always adapt the systems
to changed process demands. This results in low initial investment and
low running costs.
The Bio Clave bioreactor and fermentor are available in 20, 70 and 110
liter total volume. All systems are equipped with a top driven stirrer
who can be either a magnetically coupled or a lipsealed stirrer system.
Bioreactors and fermentors
Applikon Bio Clave bioreactor and fermentor systems
are designed for maximum flexibility in setting up. The reactor headplate
only has entry ports and no welded pipes. This means that the systems
can be completely customized for the user's application. When the application
changes, the bioreactor set-up can easily be adapted to the changed process
demands. Headplates are made of 316L stainless steel and all parts in
the bioreactors have an electropolished finish that ensures reliable cleanability
of the vessel and components. Vessels can be used up to 3.1 barg of overpressure.
|
Type
|
Total volume
|
Working volume
|
Minimum working
volume
|
H/D ratio total
volume
|
H/D ratio working
volume
|
|
20
|
21.9
|
14.6
|
4.4
|
3.0
|
2.0
|
|
70
|
74.2
|
49.5
|
13.7
|
3.0
|
2.0
|
|
110
|
110.0
|
73.3
|
20.3
|
2.8
|
1.9
|
Vessel Volumes
- 20, 70 or 110L total volumes
Vessel Construction
- Interior Finish EP to Ra=0.8µm
- Exterior Mirror Polish
- Designed to ASME, Sec.VIII, Div.1
- Flush Mounted Longitudinal sight glass
- H:D Total Volume 3.1
Top Drive DC Motor
Lipseal or Magnetic Stirrers
Ports:
- Head plate: 1x69.2mm,3x1.5"TC,4x27
& 3x16mm
- Upper Side Wall: 5x27mm - Lower Side Wall: 5xDN25
Many Auxiliaries
| |
Bio Clave
20L |
Bio Clave
70L |
Bio Clave
110L |
| Bio Clave reactor
type |
20 liter |
70 liter |
110 liter |
| Inner Diameter |
211 mm |
316 mm |
370 mm |
| Inner Height
(max.) |
631 mm |
957 mm |
1043 mm |
| Liquid Height
(working vol.) |
444 mm |
678 mm |
764 mm |
| Ports Head
Space section |
5 x 27 mm |
5 x 27 mm |
5 x 27 mm |
| Ports Bottom
section |
5 x DN 25 |
5 x DN 25 |
5 x DN 25 |
| Ports Head Plate: |
|
|
|
| |
1 x 69 mm |
1 x 69 mm |
1 x 69 mm |
| |
3 x 16 mm |
3 x 16 mm |
3 x 16 mm |
| |
4 x 27 mm |
4 x 27 mm |
4 x 27 mm |
| |
3 x 1.5"TC |
3 x 1.5"TC |
3 x 1.5"TC |
| Autoclave Space (HxD) |
1200 x 400 mm |
1200 x 400 mm |
1985 x 650 mm |
| Overall height reactor |
715 mm |
715 mm |
1110 mm |
| Total Volume |
20 liter |
20 liter |
110 liter |
| Working Volume |
15 liter |
15 liter |
80 liter |
| Min. Working Volume |
4 liter |
4 liter |
21 liter |
| H/D Total |
3 |
3 |
3 |
| H-D Work Vol. |
2.2 |
2.2 |
2.2 |
| Design Pressure Reactor |
4.1 bar |
4.1 bar |
4.1 bar |
| Test Pressure Reactor |
4.8 bar |
4.8 bar |
4.8 bar |
| Design Pressure Jacket |
6.2 bar |
6.2 bar |
6.2 bar |
| Test Pressure Jacket |
11.2 bar |
11.2 bar |
11.2 bar |
| Max. Temperature Reactor |
130 °C |
130 °C |
130 °C |
|
